Brain activity underlying impaired continence control in older women with overactive bladder
Neurourology and Urodynamics, 04/18/2012
Tadic SD et al. – In older women with overactive bladder (OAB), brain activity in the supplementary motor area is greater among those with more easily elicitable detrusor overactivity, suggesting a compensatory response to failure of control elsewhere. OAB is heterogeneous; one possible phenotype shows severe functional impairment attributable partly to age–related white matter changes. Functional brain imaging coupled with urodynamics may provide CNS markers of impaired continence control in subjects with OAB.