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Proton Pump Inhibitors and Pain
Pain Physician, 11/25/09

Smith HS et al. – The authors theorize that there may be a possible correlation between proton pump inhibitors (PPIs) and the symptoms (e.g. pain) associated with restless legs syndrome (RLS). The authors propose that PPIs, such as omeprazole, may interfere with iron absorption in certain patients and that a subpopulation of patients who develop significant iron deficiency characterized by low serum ferritin levels while on PPIs may also develop RLS–like symptoms (including RLSAP). While there is no robust direct evidence to support any associations of PPIs and iron deficiency or PPIs associated with RLS–like symptoms (including RLSAP), it is hoped that this manuscript may spark research efforts on this issue.

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