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See Latest ArticlesAIRE activated tissue specific genes have histone modifications associated with inactive chromatin
Human Molecular Genetics, 11/25/09
Org T et al. – The findings provide several clues of AIRE's function in mTECs. It provides a mechanistic explanation of how, based on epigenetic histone marks, AIRE is guided to its target genes in the thymus. This implies that AIRE is not recruited to tissue–specific antigen genes per se, but instead, AIRE identifies its target genes by a specific histone code, which can often be found on tissue–specific gene promoters outside of the tissues in which they are expressed.
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