Internal Med

Your Article Summary

See Latest Articles

Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus
Arthritis Care and Research , 01/05/09

Hersh AO et al. – Study demonstrates important differences in the outcomes of patients with childhood systemic lupus erythematosus (cSLE) and adult SLE (aSLE), and provides important prognostic information about long-term SLE disease activity and treatment.

• Aim was to compare differences in long-term outcome cSLE and aSLE
• Data derived from a cohort of 885 adult subjects with SLE (90 cSLE, 795 aSLE)
• Baseline and 1-yr f/u data obtained via structured 1-hr telephone interviews
• Differences in organ involvement and disease morbidity, current disease status and activity, past and current medication use, and number of physician visits were compared

• Average disease duration for cSLE and aSLE subgroups was 16.5 and 13.4 yrs, respectively
• Mean age at f/u was 30.5 and 49.9 yrs, respectively
• cSLE subjects had a higher frequency of SLE-related renal disease, whereas aSLE subjects were more likely to report a history of pulmonary disease
• Rates of clotting disorders, seizures, and myocardial infarction were similar between the 2 groups
• At f/u, cSLE subjects had lower overall disease activity, but were more likely to be taking steroids and other immunosuppressive therapies
• Total number of yearly physician visits was similar between the 2 groups, although cSLE subjects had a higher number of nephrology visits

Today in Orthopedic/Physical Med...keeping you current

Receive free subspecialty "5-minute updates" via email

Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09

Doxycycline for osteoarthritis of the knee or hip
Cochrane Reviews, 10/23/09

Bisphosphonate therapy: When not to monitor BMD
The Journal of Family Practice, 11/02/09

See All of Orthopedic/Physical Med