Internal Med Medical News about SLE;long-term disease activity and treatment

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Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus
Arthritis Care and Research , 01/05/09

Hersh AO et al. – Study demonstrates important differences in the outcomes of patients with childhood systemic lupus erythematosus (cSLE) and adult SLE (aSLE), and provides important prognostic information about long-term SLE disease activity and treatment.

Methods

Aim was to compare differences in long-term outcome cSLE and aSLE
Data derived from a cohort of 885 adult subjects with SLE (90 cSLE, 795 aSLE)
Baseline and 1-yr f/u data obtained via structured 1-hr telephone interviews
Differences in organ involvement and disease morbidity, current disease status and activity, past and current medication use, and number of physician visits were compared

Results

Average disease duration for cSLE and aSLE subgroups was 16.5 and 13.4 yrs, respectively
Mean age at f/u was 30.5 and 49.9 yrs, respectively
cSLE subjects had a higher frequency of SLE-related renal disease, whereas aSLE subjects were more likely to report a history of pulmonary disease
Rates of clotting disorders, seizures, and myocardial infarction were similar between the 2 groups
At f/u, cSLE subjects had lower overall disease activity, but were more likely to be taking steroids and other immunosuppressive therapies
Total number of yearly physician visits was similar between the 2 groups, although cSLE subjects had a higher number of nephrology visits