Internal Med

Your Article Summary

See Latest Articles

Sodium oxybate relieves pain and improves function in fibromyalgia syndrome: A randomized, double-blind, placebo-controlled, multicenter clinical trial
Arthritis & Rheumatism, 01/05/09

Russell IJ et al. – Study shows that sodium oxybate therapy was well tolerated. It significantly improved the symptoms of fibromyalgia syndrome (FMS); further studies are warranted.

• Aim was to evaluate the safety and efficacy of sodium oxybate for management of the symptoms of FMS
• FMS pts randomized, to receive 4.5 gm or 6 gm of sodium oxybate or matching placebo x1/night for 8 wks
• Primary outcome variable (POV): a composite score for changes from baseline in 3 coprimary self-report measures: PVAS, FIQ score, and PGI-C
• A beneficial response rate: 20% improvement in the PVAS and FIQ scores plus a rating of much better or very much better on the PGI-C
• Secondary measures: subjective sleep and QoL measures
• Analysis were based on an intent-to-treat (ITT) population

• ITT population included 188 pts with FMS; 78% of whom completed the trial
• Significant benefit was observed with both dosages of sodium oxybate, according to changes in POV and subjective sleep quality
• Improvements in the PVAS score were correlated with sleep outcomes
• Sodium oxybate was well tolerated overall; dose-related nausea and dizziness tended to resolve with continued therapy

Today in Orthopedic/Physical Med...keeping you current

Receive free subspecialty "5-minute updates" via email

Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09

Doxycycline for osteoarthritis of the knee or hip
Cochrane Reviews, 10/23/09

Bisphosphonate therapy: When not to monitor BMD
The Journal of Family Practice, 11/02/09

See All of Orthopedic/Physical Med