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A propensity-matched study of the association of peripheral arterial disease with cardiovascular outcomes in community-dwelling older adults
The American Journal of Cardiology, 01/05/09

A propensity-matched study of the association of peripheral arterial disease with cardiovascular outcomes in community-dwelling older adultsAronow WS et al. – In a propensity-matched well-balanced population of community-dwelling older adults, baseline peripheral arterial disease (PAD) was associated with increased all-cause mortality and cardiovascular morbidity.

• Study of the hypothesis that baseline PAD is associated with increased all-cause mortality and cardiovascular morbidity
• Analysis of public-use Cardiovascular Health Study (CHS) data for 5,795 CHS subjects: data for baseline ankle-brachial index in 5,630 pts and PAD in 767
• PAD defined as ankle-brachial index <0.9
• Calculation of propensity scores for PAD using 66 baseline covariates for each pts, matched with 679 pairs of sibjects with/without PAD
• Matched Cox regression models to estimate associations of PAD with outcomes during 7.5-yr median follow-up

• Overall, 55% of matched subjects died from all causes during 9,958 pt-yrs of follow-up
• All-cause mortality in 61% (rate 8,710/100,000 pt=yrs) and 50% (rate 6,503/100,000 pt-yrs) of subjects, with and without PAD, respectively

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