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Omission of concurrent chemoradiation after a response to neoadjuvant chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis
British Journal of Radiology, 10/26/07

Craven, I., et al. - A case study that illustrates the potential risk of omitting radiation following a good response to neoadjuvant systemic chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis.

Methods

An overview of potential risk of omitting radiation following a good response to neoadjuvant systemic chemotherapy

Results

There is clear evidence to support the use of pre-operative concurrent chemo-radiotherapy (CRT) in locally advanced rectal cancer
In the UK, most pts are selected for treatment if the resection margin is predicted to be involved
The selection criteria used includes primary tumours that threaten the resection margins on high-resolution pelvic MRI and low tumours requiring abdominoperineal excision
There is no consensus, however, to guide the treatment of pts who present with advanced rectal disease and synchronous, potentially resectable, metastatic disease

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