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See Latest ArticlesMesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
Journal of Clinical Investigation, 04/23/07
Shotaro Iwamoto, et al. - Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion. Consequently, asparaginase is a major component of ALL therapy, but the mechanisms regulating the susceptibility of leukemic cells to this agent are unclear
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