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Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells
Journal of Endocrinology, 03/02/07
E Mrak, et al. – It is presently thought that osteoprotegerin (OPG) is a cytokine involved in the regulation of osteoblast/osteoclast crosstalk and maintenance of bone mass. Recent studies showed that GH replacement therapy in GH-deficient patients was able to induce a significant increase of OPG in the plasma, as well as in the cortical and the trabecular bone
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