Your Article Summary
See Latest ArticlesSafety of Lovastatin/Extended Release Niacin Compared With Lovastatin Alone, Atorvastatin Alone, Pravastatin Alone, and Simvastatin Alone
The American Journal of Cardiology, 03/05/07
Alsheikh-Ali, Alawi A. MD., et al. – Are the label warnings about increased risk of adverse events with statin and niacin combinations valid?
>Summary: A comparison review of the rate of adverse event reports (AERs) received by the United States Food and Drug Administration from 1999 to March 2005 associated with the combination of lovastatin/niacin-extended release (ER) with those of lovastatin or niacin-ER alone, and other commonly used statins.The prevalence of concomitant niacin-ER therapy in the statin-associated AERs was also calculated.
Outcomes: The amount of serious AERs associated with the combination lovastatin/niacin-ER was similar to that of lovastatin or niacin-ER alone, and significantly less than that of atorvastatin or simvastatin used alone. The rates of liver and rhabdomyolysis AERs associated with lovastatin/niacin-ER were similar to those of the other statins or niacin-ER uses alone and lower than those associated with simvastatin alone. The incidence of niacin-ER use in statin-associated AERs was less than 1%. The findings indicate that statins can safely be used in combination as indicated in the national guidelines
Related Articles
Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite, norverapamil in rats: Possible role of P-glycoprotein inhibition by lovastatin
Archives of Pharmacal Research, 11/16/09
Relevance Score: 90%
UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
EurekAlert, 11/04/09
Relevance Score: 84%
Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations
Investigational New Drugs, 10/08/09
Relevance Score: 84%
Red yeast rice: A natural approach to high cholesterol
Internet Source, 10/28/09
Relevance Score: 80%
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: Results of the ICARIA study
Atherosclerosis, 12/04/09
Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case–control study
Atherosclerosis, 12/04/09
Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia
Atherosclerosis, 12/04/09
Today in Cardiology...keeping you current
Receive free subspecialty "5-minute updates" via email
Foam sclerotherapy: cardiac and cerebral monitoring
Phlebology, 12/04/09
Comparison of Antero-Lateral Versus Antero-Posterior Electrode Position for Biphasic External Cardioversion of Atrial Flutter
The American Journal of Cardiology, 12/04/09
Usefulness of Non-Invasive Measurement of Cardiac Output During Sub-Maximal Exercise to Predict Outcome in Patients With Chronic Heart Failure
The American Journal of Cardiology, 12/04/09
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Divalproex Sodium-Induced Eosinophilic Pleural Effusion
American Journal of Therapeutics, 12/04/09
Lithium and thyroid
Best Practice & Research Clinical Endocrinology & Metabolism, 12/04/09
Acute Generalized Exanthematous Pustulosis: A Rare Clinical Entity With Use of Piperacillin/Tazobactam
American Journal of Therapeutics, 12/04/09