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See Latest ArticlesThe molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin
Journal of Lipid Research, 03/02/07
Dawn E. Telford, et al. – The combination of ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein (NPC1L1), and an HMG-CoA reductase inhibitor decreases cholesterol absorption and synthesis. In clinical trials, ezetimibe plus simvastatin produces greater LDL-cholesterol reductions than does monotherapy. The molecular mechanism for this enhanced efficacy has not been defined
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