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See Latest ArticlesPredictors of response and survival for neoadjuvant treated patients with esophageal adenocarcinoma
Diseases of the Esophagus, 05/05/08
Theisen J et al. – A gene expression profile before therapy has a potential predictive value in neoadjuvant-treated esophageal adenocarcinoma pt
Methods- Study of genetic predictors of response and survival for esophageal adenocarcinoma 32 pts prior to neoadjuvant therapy
- Thymidylate synthase (TS), excision repair cross complementing (ERCC1) and Gluthatione S-transferase (GSTP-1) mRNA levels assessed prior to neoadjuvant therapy
- Results analyzed in terms of response and survival
- Of 18 responders to the protocol, 17 had a gene expression level at or below the respective median of at least 1 gene
- Survival increased for patients with TS, ERCC1, or GSTP-1 mRNA level at or below the median
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