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Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: Is there really a difference
Diseases of the Esophagus, 05/05/08

Vallbohmer D et al. - Total number of patients with adenocarcinoma of the esophagus increased dramatically, but the number of young patients remained rather constant in the european population included in this study, mainly due to less comorbidity and more frequent use of neoadjuvant therapy.

Methods

Aim was to compare clinicopathologic and prognostic factors of young and elderly pts with esophageal adenocarcinoma
223 pts were analyzed and divided in 3 groups: (i) pts <=50 yrs (n=40); (ii) pts between 50-70 yrs (n=131); and (iii) pts >70 yrs (n=52)
Clinicopathological and prognostic factors were compared between these groups

Results

Total no. of pts with esophageal adenocarcinoma increased significantly
Although the total no. of pts <=50 yrs increased over the yrs, the proportion of young pts remained constant
The no. of pts with a pT1-tumor was similar among all groups
Young pts had a lower comorbidity and received more often a neoadjuvant radio-chemotherapy
The 5-yr survival rate of young pts was significantly higher vs elderly pts

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