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Morinishi Y et al. – TRECs were extremely low in all neonatal Guthrie cards (n=15) and peripheral blood (n=14) from patients with SCID, including those with maternal T–cell engraftment or leaky T cells with hypomorphic RAG1 mutations or LIG4 deficiency. There were no false–positive or negative results in this study. TRECs quantification can be used as a neonatal mass screening for patients with SCID.

   

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