Top scid Articles in Internal Medicine

Stepped Care Treatment of Postpartum Depression: Impact on Treatment, Health, and Work Outcomes
Journal of the American Board of Family Medicine, 09/08/2009

infants from 7 clinics completed surveys at 0 to 1, 2, 4, 6, and 9 months postpartum and a Structured Clinical Interview for DSM–IV (SCID). SCID–positive depressed women were randomized to stepped collaborative care or usual care. Nine–month treatment, health, and ... nondepressed women. Results 45 women had SCID–positive depression whereas 122 had self–diagnosed depression. For SCID–positive depressed women, the stepped care intervention increased mothers’ awareness of their depression diagnosis and their [more...]

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
Blood, 08/20/2009

Cassani B et al. – The results confirm that RV–mediated gene transfer for ADA–SCID is safe, and provide crucial information for the development of future gene therapy [more...]

Identification of Severe Combined Immunodeficiency by T-Cell Receptor Excision Circles Quantification Using Neonatal Guthrie Cards
The Journal of Pediatrics, 08/12/2009

with SCID, including those with maternal T–cell engraftment or leaky T cells with hypomorphic RAG1 mutations or LIG4 deficiency. There were no false–positive or negative results in this study. TRECs quantification can be used as a neonatal mass screening for patients with SCID [more...]

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
Blood, 08/05/2009

Cassani B et al. – The results confirm that RV–mediated gene transfer for ADA–SCID is safe, and provide crucial information for the development of future gene therapy [more...]

The modified SCID Hypomania Module (SCID-Hba): A detailed systematic phenomenologic probing
Journal of Affective Disorders, 09/09/2009

Benazzi F et al. – Presenting mood change as simply having been more elated/irritable than usual can easily be interpreted as normal mood fluctuations, while presenting mood change as much more than [more...]

Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages
Haematologica, 08/28/2009

Briquet A et al. – Extended MSC culture alters their supportive ability toward HPC [more...]

Reduced immunoglobulin class switch recombination in the absence of Artemis
Blood, 08/24/2009

Rivera–Munoz P et al. – Significant increase in DNA microhomology usage is the signature of CSR junctions obtained from human RS–SCID patients harboring hypomorphic Artemis mutations. Altogether this indicates that Artemis participates in the repair of a subset of DNA breaks [more...]

Rapid full engraftment and successful immune reconstitution after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in Omenn syndrome
Pediatric Transplantation, 08/20/2009

Gozdzik J et al. – OS is a variant of SCID characterized by generalized erythroderma, alopecia, eosinophilia, and elevated IgE levels. It is fatal unless treated with allogeneic HSCT, which is the [more...]

A recombinant Listeria monocytogenes expressing a cell wall-associated listeriolysin O is poorly virulent but immunogenic
Infection and Immunity, 08/24/2009

Carrero JA et al. – The sLLO strain was cleared by severe combined immunodeficient (SCID) mice. Despite the attenuation of virulence, sLLO was immunogenic and capable of eliciting protective T cell responses. [more...]

Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc
Human Immunology, 09/16/2009

Vlad G et al. – Using a hu–nonobese diabetic/severe combined immunodeficiency (hu–NOD/SCID) gamma–null model of xenogeneic GVHD, the authors have demonstrated that treatment with recombinant immunoglobulin–like transcript 3 [more...]