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After the initial infection, both HSV and VZV enter a latent state in nerve cells of the infected host. Periodically these viruses can reactivate to produce infection and disease. The researchers demonstrated that, in addition to preventing infection, the MAOI drug TCP also prevented HSV reactivation. Importantly, says Dr. Kristie, the study contributes to the understanding of the mechanisms used by these viruses to infect host cells and of their cycles of latency–reactivation.


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