Top meningitis Articles in Infectious Disease

Dementia and capsular genu ischemia in patients with severe bacterial meningitis
Neurological Sciences, 11/02/2009

Naito M et al. – In patients with severe bacterial meningitis, capsular genu ischemia may play some role in the development of post–meningitis dementia. In patients with viral meningitis, absence of such ischemia may explain, at ... meningitis dementia. [more...]

Costs for Households and Community Perception of Meningitis Epidemics in Burkina Faso
Clinical Infectious Diseases, 10/28/2009

Colombini A et al. – Respondents reported combining traditional and modern beliefs regarding disease etiology, which in turn influenced therapeutic care–seeking behavior. Households spent US $90 per meningitis case, or 34% of the ... domestic product per capita, and up to US $154 more when meningitis sequelae occurred. Much of this cost was attributable to direct medical expenses, which in theory are paid by the government. Preventive immunization against meningitis will overcome limitations imposed by traditional beliefs and ... cns infectious disease [more...]

Corticosteroids (dexamethasone versus intravenous methylprednisolone) in patients with tuberculous meningitis
Annals of Tropical Medicine and Parasitology, 10/15/2009

Malhotra HS et al. – In an open–label study in India, 97 patients with such meningitis were randomized into a control group, a dexamethasone group (with the drug given intravenously once a day ... equally reported in the two corticosteroid groups. Larger trials are still needed to determine if dexamethasone and/or methylprednisolone are useful in the treatment of tuberculous meningitis, at least in India. [more...]

Prevalence and antimicrobial resistance pattern of bacterial meningitis in Egypt
Annals of Clinical Microbiology and Antimicrobials, 10/13/2009

Shaban L et al. – This article addresses profound bacterial agents causing a wide array of infections including but not limited to pneumonia and meningitis. The epidemiology of such infectious diseases and the prevalence ... and Haemophilus influenzae are reviewed in the context of bacterial meningitis. The authors address prevalent serotypes in Egypt, antimicrobial resistance patterns and efficacy of vaccines to emphasize the importance of periodic surveillance for appropriate preventive and treatment strategies ... neuro/psych pharmacology [more...]

Adhesion molecule levels in serum and cerebrospinal fluid in children with bacterial meningitis and sepsis
Journal of Pediatric Neurosciences, 11/03/2009

Jaber SM et al. – This study supports the role of adhesion molecules especially sL–selectin, sVCAM–1 in meningitis and suggests further research to determine their use as biomarkers for meningitis and use of their antagonists as ... The presence of discrepancy of CSF/serum ratios for molecules of same molecular weight suggest intrathecal shedding in addition to diffusion through the blood–CSF barrier. [more...]

Oxidative stress and S-100B protein in children with bacterial meningitis
BMC Neurology, 10/15/2009

Hamed SA et al. – This study suggests that loss of integrity of brain–CSF barriers, oxidative stress and S–100B may contribute to the severity and neurological complications of bacterial meningitis. [more...]

Immunological and Biochemical Correlates of Adjunctive Dexamethasone in Vietnamese Adults with Bacterial Meningitis
Clinical Infectious Diseases, 10/14/2009

Mai NTH et al. – Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and ... after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo. [more...]

Therapy of community-acquired acute bacterial meningitis: the clock is running
Expert Opinion in Pharmacotherapy, 10/20/2009

Klein M et al. – Despite antibiotic therapy and supportive intensive medical care, bacterial meningitis remains a disease with high mortality and morbidity. Rapid recognition of symptoms is crucial to direct ... and, initially, empiric antibiotic therapy. It has become evident that time from arrival at the hospital to application of the first dose of antibiotics is a crucial independent factor that influences outcome. [more...]

Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis
Neurology, 11/06/2009

Schut ES et al. – Delayed cerebral thrombosis may occur in patients with excellent recovery from pneumococcal meningitis. All patients were treated initially with adjunctive dexamethasone therapy, suggesting ... immunologic reaction targeting cerebral blood vessels. [more...]

Impact of Bacille Calmette-Guerin Vaccination on Neuroradiological Manifestations of Pediatric Tuberculous Meningitis
Journal of Child Neurology, 10/01/2009

Wasay M et al. – A total of 108 pediatric patients with tuberculous meningitis were included in the analysis. Of the 108 patients, 63 were male and 45 had received bacille Calmette ... on MRI, which were significantly higher in the non–bacille Calmette–Guerin vaccinated group. [more...]