Top hsv Articles in Infectious Disease

Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
Journal of Virology, 10/26/2009

alanine substitution in HSV–2 Us3 at a site corresponding to one that can be autophosphorylated in HSV–1 Us3 abolished HSV–2 Us3 kinase activity. Thus, the regulatory and functional effects of Us3 kinase activity are different between HSV–1 and HSV–2. [more...]

Maternal and Neonatal Herpes Simplex Virus Infections
Internet Source, 10/20/2009

with herpes simplex virus type 1 (HSV–1) or HSV type 2 (HSV–2).1 Neonatal HSV infection, defined as infection in a newborn within 28 days after birth, is an especially devastating consequence of the epidemic of genital herpes. Untreated neonatal HSV infection is associated with only a 40 [more...]

Concentrated and linked epidemics of both HSV-2 and HIV-1/HIV-2 infections in Senegal: public health impacts of the spread of HIV
International Journal of STD & AIDS, 10/30/2009

Kane CT et al. – HIV epidemic remains concentrated in high–risk groups of the Senegalese population, such as the FSW population in which the seroprevalence of HSV–2 infection ... Intervention against STI including HSV–2 is urgently needed to prevent the spreading of HIV epidemic. [more...]

Maternal and Neonatal Herpes Simplex Virus Infections
Internet Source, 10/02/2009

infection with herpes simplex virus type 1 or HSV type 2. Neonatal HSV infection, defined as infection in a newborn within 28 days after birth, is an especially devastating consequence of the epidemic of genital herpes. Untreated neonatal HSV infection is associated with only a 40% survival rate [more...]

Maternal and Neonatal Herpes Simplex Virus Infections
Internet Source, 10/01/2009

infection with herpes simplex virus type 1 or HSV type 2. Neonatal HSV infection, defined as infection in a newborn within 28 days after birth, is an especially devastating consequence of the epidemic of genital herpes. Untreated neonatal HSV infection is associated with only a 40% survival rate [more...]

Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing
Journal of Neuroimmunology, 11/02/2009

Conrady CD et al. – Although rare, HSV–1 is the leading cause of frank sporadic encephalitis that, if left untreated, can result in death. A greater understanding of the contribution of ... infiltrating leukocytes within the CNS in response to HSV–1 invasion is necessary to identify candidate molecules as targets for therapeutic intervention to reduce unwarranted inflammation coinciding with the maintenance of the anti–viral state. [more...]

Certain Antidepressants May Inhibit Herpesvirus Infection and Reactivation
National Institute of Allergy and Infectious Disease - News, 10/29/2009

infection, both HSV and VZV enter a latent state in nerve cells of the infected host. Periodically these viruses can reactivate to produce infection and disease. The researchers demonstrated that, in addition to preventing infection, the MAOI drug TCP also prevented HSV reactivation. Importantly [more...]

Decreasing Prevalence of Herpes Simplex Virus-2 Antibodies in Selected Groups of Women in Sweden
Acta Dermato-Venereologica, 10/27/2009

Berntsson M et al. – The overall HSV–2 prevalence was 10.4% for the pregnant women and 25.2% for the female attendees at the clinic for sexually transmitted infections. The seroprevalence of HSV–2 in pregnant women appears to have decreased in Sweden during the [more...]

Comparison of Focus HerpesSelect(R) and KalonTM HSV-2 gG2 ELISA serological assays to detect herpes simplex virus type 2 antibodies in a South African population
Sexually Transmitted Infections, 10/22/2009

Delany–Moretlwe S et al. – Newer HSV–2 serological tests have low specificity in this South African population with [more...]

Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1
Proceedings of the National Academy of Sciences of the United States of America, 10/23/2009

contrast with recent findings that (i) either HVEM or nectin–1 can permit HSV infection of the vaginal epithelium in mice and (ii) nectin–1 is not the sole receptor capable of enabling spread of HSV infection from the vaginal epithelium to the PNS and CNS. [more...]