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Fleurence RL et al. - The annual health care costs of human papillomavirus–related conditions in the United States range from $2.25 to $4.6 billion (2005 US dollars). The burden of human papillomavirus is second only to human immunodeficiency virus among sexually transmitted diseases. Health-related quality-of-life areas that are impacted substantially by human papillomavirus include emotional, social, and sexual functioning.

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