Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesFive-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: A phase II study
Neurosurgery, 11/25/09
Arya N et al. – 5-ALA fluorescence has a high predictive value for the detection of tumor in recurrent gliomas. Prior treatment modalities, such as radiation or chemotherapy, do not invalidate the fluorescence guidance with 5-ALA. 5-ALA fluorescence guidance is an effective surgical adjunct in the surgery of recurrent malignant gliomas
Methods- Multicenter prospective, single-arm, uncontrolled phase II study, 36 patients with recurrent glioma (World Health Organization grade III/IV) received 5-ALA before surgery
- After microsurgical resection, biopsies from pathological and nonpathological areas (as identified under conventional white light) were obtained to determine the positive predictive value (PPV) of 5-ALA-induced tissue fluorescence in detecting tumors
- Adverse events, neurological examinations, and survival data documented for minimal follow-up of 6 mos
- Patient-based PPV, defined as percentage of patients showing positive tumor cell identification in all biopsies taken from areas of weak and strong fluorescence was 97.2% for pathological areas and 79.4% in nonpathological areas
- Within areas of strong fluorescence, PPV higher (91.7%) compared with that of weak fluorescence (82.4%)
- On biopsy level for nonpathological-appearing tissue under white light (157 biopsies) the PPV of tissue fluorescence was 93.0% compared with 99.5% in pathological-appearing tissue (197 biopsies)
- Within areas of strong fluorescence, PPV was higher (96.9%) compared with that of weak fluorescence (90.3%)
- No adverse events pertaining to study drug
Related Articles
Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1
Journal of Neuro-Oncology, 11/19/09
Relevance Score: 90%
Height, Body Mass Index, and Physical Activity in Relation to Glioma Risk
Cancer Research, 11/02/09
Relevance Score: 90%
Diagnostic and prognostic markers in gliomas
Current Opinion in Oncology, 10/13/09
Relevance Score: 90%
Novel insights into the pathogenesis of gliomas based on large-scale molecular profiling approaches
Current Opinion in Neurology, 11/11/09
Relevance Score: 89%
Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy
International Journal of Cancer, 11/10/09
Relevance Score: 89%
Today in Neurologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors
Cancer Chemotherapy and Pharmacology, 02/09/10
Phase II study of pemetrexed in patients with advanced neuroendocrine tumors
Cancer Chemotherapy and Pharmacology, 02/09/10
Therapy-induced antitumor vaccination in neuroblastomas by the combined targeting of IL-2 and TNF-alpha
International Journal of Cancer, 02/09/10
Article Search
Sponsor
Sponsor