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See Latest ArticlesInvestigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma
BMC Cancer, 11/25/09
Abdulamir AS et al. – S. gallolyticus most likely plays an essential role in the oncogenic progression of normal colorectal mucosa to adenoma and to CRC. This promoting/propagating role of S. gallolyticus might take place by utilizing certain inflammatory, anti-apoptotic, and angiogenic factors of transformation
Methods- ELISA used to measure IgG antibodies of S. gallolyticus and B. fragilis in sera of 50 colorectal cancer, 14 colorectal adenoma patients, 30 age- and sex- matched apparently healthy volunteers (HV) and 30 age- and sex- matched colonoscopically-proven tumor-free control subjects
- NF-kappaB and IL-8 mRNA expression evaluated in tumorous and non-tumorous tissue sections of carcinoma and adenoma patients in comparison with that of control subjects by using in situ hybridization assay
- Colorectal cancer and adenoma patients associated with higher levels of serum S. gallolyticus IgG antibodies in comparison with HV and control subjects while no similar association found with serum IgG antibodies of B. fragilis
- ELISA cutoff value for seropositivity of S. gallolyticus IgG calculated from tumor-free control group
- Expression of NF-kappaB mRNA higher in tumorous than non-tumorous tissue sections of adenoma and carcinoma, higher in carcinoma/adenoma sections than in control subjects, higher in tumorous sections of carcinoma than in adenoma patients, and higher in S. gallolyticus IgG seropositive than in seronegative groups in both tumorous and non-tumorous sections (P < 0.05). IL-8 mRNA expression in tumorous sections of adenoma and carcinoma was higher than in non-tumorous sections, higher in carcinoma/adenoma than in control subjects, and higher in S. gallolyticus IgG seropositive than in seronegative groups in tumorous rather than non-tumorous sections
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