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See Latest ArticlesInduction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: Results from a phase II prospective trial
Journal of Clinical Oncology, 11/25/09
Kies MS et al. – ICT with weekly PCC followed by risk-based local therapy seems to be feasible, effective, and well tolerated. PFS is promising, and this sequential treatment strategy should be further investigated. Patients with HPV-positive tumors have an excellent prognosis.
Methods- 47 previously untreated patients (41 with oropharynx primaries; 33 men, 14 women; median age, 53 years; performance status of 0 or 1) with squamous cell carcinoma of head and neck (SCCHN; T1-4, N2b/c/3) treated and evaluated for clinical and radiographic response
- After ICT, patients underwent risk-based local therapy, which consisted of either radiation, concomitant chemoradiotherapy, or surgery, based on tumor stage and site at diagnosis
- After induction PCC, nine patients (19%) achieved a complete response, and 36 patients (77%) achieved partial response
- Most common grade 3 or 4 toxicity was skin rash (45%), followed by neutropenia (21%) without fever
- At median follow-up time of 33 months, locoregional or systemic disease progression observed in 6 patients
- 3-year PFS and OS rates 87% (95% CI, 78% to 97%) and 91% (95% CI, 84% to 99%), respectively
- HPV 16, found in 12 (46%) of 26 biopsies, associated with improved PFS and OS
Today in Head and Neck...keeping you current
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Current Trends in the Follow-up of Head and Neck Cancer Patients in the UK
Clinical Oncology, 02/05/10
Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells
Molecular Cancer, 02/04/10
Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma
International Journal of Cancer, 02/04/10
Today in Pharmacology/Therapy...keeping you current
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Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): A phase II randomised trial
The Lancet Oncology - Online First, 02/09/10
Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors
Cancer Chemotherapy and Pharmacology, 02/09/10
A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer
Cancer Chemotherapy and Pharmacology, 02/09/10
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