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Downregulation of GATA-2 and overexpression of adipogenic gene-PPARgamma in mesenchymal stem cells from patients with aplastic anemia
Experimental Hematology, 11/25/09
Xu Y et al. – These findings indicate that fatty marrow replacement in AA patients can be explained by downregulation of GATA–2 and overexpression of PPARgamma in MSCs. Decreased expression of GATA–2 might be responsible for the pathogenesis and development of the clinical features of the disease.
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