Oncology Medical News about sickle-cell syndromes

D Scott Cunningham MD, PhD
The Best of 2009

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The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle-cell syndromes: results of a 17-year, single center trial (LaSHS)
Blood, 11/25/09

Voskaridou E et al. – The multivariate analysis showed that HbF values at baseline and percentage change of LDH between baseline and 6–month were independently predicted for survival in the HU group. These results highlight the beneficial effect of HU which seems to modify the natural history of SCD and raise the issue of expanding its use in all SCD patients.

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