Your Article Summary
See Latest ArticlesHER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and lapatinib efficacy in women with metastatic breast cancer
Clinical Cancer Research, 12/08/08
Press MF et al. - Women with HER-2-positive metastatic breast cancer (BCa) benefit from lapatinib, whereas women with HER-2-negative metastatic BCa derive no incremental benefit from this treatment.
Methods- Aim was to analyze the biomarkers from two randomized phase III trials to optimize selection of pts for lapatinib therapy
- Breast cancer tissue from EGF30001 and EGF100151 trials analyzed for:
- HER-2 gene amplification by FISH
- HER-2 mRNA by RT-PCR
- HER-2 protein expression by HercepTest IHC
- EGFR mRNA level by RT-PCR, and EGFR protein by IHC
- All compared with clinical outcomes
- HER-2 gene amplified in 47% and IHC was 3+ in 35%
- Positive EGFR immunostaining in 28% correlated with EGFR mRNA levels by RT-PCR
- HER-2 gene amplification/overexpression associated with improved clinical outcomes in both trials
- An improvement in outcome was seen in FISH-positive and IHC 0, 1+, or 2+ pts
- HER-2 mRNA expression correlated with HER-2 FISH and IHC status
- No correlation between EGFR expression and responsiveness to lapatinib regardless of HER-2 status
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Decreased expression of KLF6 and its significance in gastric carcinoma
Medical Oncology, 12/17/09
Fas Ligand (FasL, Apo-1L/CD95L) Expression and Clinical Outcome in Papillary Microcarcinoma and Papillary Thyroid Carcinomas with Diameter Smaller than 1.5 Centimeters
Experimental and Clinical Endocrinology & Diabetes, 12/16/09
Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue
Oral Oncology , 12/16/09
Today in Breast...keeping you current
Receive free subspecialty "5-minute updates" via email
Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis
Oncogene, 12/16/09
Copine-III interacts with ErbB2 and promotes tumor cell migration
Oncogene, 12/16/09
Mechanisms of breast cancer bone metastasis
Cancer Letters, 12/16/09