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HER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and lapatinib efficacy in women with metastatic breast cancer
Clinical Cancer Research, 12/08/08
Press MF et al. - Women with HER-2-positive metastatic breast cancer (BCa) benefit from lapatinib, whereas women with HER-2-negative metastatic BCa derive no incremental benefit from this treatment.
Methods- Aim was to analyze the biomarkers from two randomized phase III trials to optimize selection of pts for lapatinib therapy
- Breast cancer tissue from EGF30001 and EGF100151 trials analyzed for:
- HER-2 gene amplification by FISH
- HER-2 mRNA by RT-PCR
- HER-2 protein expression by HercepTest IHC
- EGFR mRNA level by RT-PCR, and EGFR protein by IHC
- All compared with clinical outcomes
- HER-2 gene amplified in 47% and IHC was 3+ in 35%
- Positive EGFR immunostaining in 28% correlated with EGFR mRNA levels by RT-PCR
- HER-2 gene amplification/overexpression associated with improved clinical outcomes in both trials
- An improvement in outcome was seen in FISH-positive and IHC 0, 1+, or 2+ pts
- HER-2 mRNA expression correlated with HER-2 FISH and IHC status
- No correlation between EGFR expression and responsiveness to lapatinib regardless of HER-2 status
Today in Basic Science/Genetics...keeping you current
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Activating Peroxisome Proliferator-Activated Receptor gamma Mutant Promotes Tumor Growth In vivo by Enhancing Angiogenesis
Cancer Research, 12/20/09
Extracellular Signal–Regulated Kinase Signaling Pathway Regulates Breast Cancer Cell Migration by Maintaining slug Expression
Cancer Research, 12/20/09
hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration
Cancer Research, 12/20/09
Today in Breast...keeping you current
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Extracellular Signal–Regulated Kinase Signaling Pathway Regulates Breast Cancer Cell Migration by Maintaining slug Expression
Cancer Research, 12/20/09
Breast cancer with non-inflammatory skin involvement: Current data on an underreported entity and its problematic classification
The Breast, 12/19/09
Flat epithelial atypia is a common subtype of B3 breast lesions and associated with noninvasive cancer but not with invasive cancer in final excision histology
Human Pathology, 12/19/09
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