Oncology Medical News about Growth Factor-beta Signaling in Ovarian Cancer

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Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-beta Signaling in Ovarian Cancer
Cancer Research, 09/06/06

Jan S. Sunde, et al. - Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-beta (TGF-beta); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers to identify signaling pathways involved in ovarian cancer

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