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Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner
Gynecologic Oncology, 08/23/06

Xiaojuan Yan, et al. - Resistance to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer...Conclusion: Taken together, these data suggest that PTEN over-expression may represent a novel therapeutic approach for chemoresistant human ovarian cancer and that this may involve a p53-mediated apoptotic cascade independent of the PI3K/Akt pathway

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