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See Latest ArticlesGenetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
Breast Cancer Research, 10/26/09
Neuhausen SL et al. – This is the first study to investigate the role of genetic variation in IGF signaling and breast cancer risk in women carrying deleterious mutations in BRCA1 and BRCA2. We identified significant associations in variants in IGF1R and IRS1 in BRCA1 carriers and in IGFBP2 in BRCA2 carriers.
Methods- Cohort of 1,665 adult, female mutation carriers, including 1,122 BRCA1 carriers (433 cases) and 543 BRCA2 carriers (238 cases)
- Genotyped for single nucleotide polymorphisms (SNPs) in IGF1, IGF1 receptor (IGF1R), IGF1 binding protein (IGFBP1), IGFBP2, IGFBP5, and IGF receptor substrate 1 (IRS1)
- Cox proportional hazards regression used to model time from birth to diagnosis of breast cancer for BRCA1 and BRCA2 carriers separately
- For linkage disequilibrium (LD) blocks with multiple SNPs, an additive genetic model assumed and for single SNP analyses no additivity assumptions made
- Among BRCA1 carriers, significant associations found between risk of breast cancer and LD blocks in IGF1R
- Among BRCA2 carriers, an LD block in IGFBP2 was found to be associated with time to breast cancer diagnosis
- No significant LD block associations found for other investigated genes among BRCA1 and BRCA2 carriers
Today in Basic Science/Genetics...keeping you current
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Today in Breast...keeping you current
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c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells
Oncogene, 11/25/09
Adenosine A1 receptor, a target and regulator of estrogen receptor action, mediates the proliferative effects of estradiol in breast cancer
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Extrapulmonary small cell carcinoma in breast and prostate
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