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See Latest ArticlesSelecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers
BMC Cancer, 10/14/09
Miolo GM et al. – These findings suggest that the IHC analysis by Allred's method improves our ability to select patients for BRCA1 testing.
Methods- Primary breast tumours from 93 FBC patients defined by specific eligibility criteria, based on personal and familial tumour history, evaluated by Allred's method
- BRCA1 molecular analysis, including Multiplex Ligation-dependent Probe Amplification (MLPA), considered as gold standard assay
- Total of 10 BRCA1 pathogenetic mutations found
- With exclusion of tumours characterized by double positive receptorial status and/or strong HER2 positivity (3+)
- Identified 22 patients, 10 of whom resulted as BRCA1 mutation carriers
- Sensitivity, specificity, positive and negative predictive values 100%, 83.3%, 45.4% and 100% respectively
Today in Basic Science/Genetics...keeping you current
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Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell–fibronectin adhesion of colon cancer cells
Oncogene, 11/25/09
A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy
Oncogene, 11/25/09
Embryoid body formation of human amniotic fluid stem cells depends on mTOR
Oncogene, 11/25/09
Today in Breast...keeping you current
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c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells
Oncogene, 11/25/09
Adenosine A1 receptor, a target and regulator of estrogen receptor action, mediates the proliferative effects of estradiol in breast cancer
Oncogene, 11/25/09
Extrapulmonary small cell carcinoma in breast and prostate
Clinical and Translational Oncology, 11/25/09
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