Zhai X et al. – Polymorphisms of the NEIL2 gene may be markers for risk and progression of squamous cell carcinomas of the oral cavity and oropharynx (SCCOOP), particularly in oropharyngeal cancer pts Methods
Study of the association between NEIL1 and NEIL2 polymorphisms and cancer risk
Genotype and haplotypes of the NEIL1 NT_010194.16:g.46434077G>T (rs7182283) and g.46438282C>G (rs4462560) and NEIL2 NT_077531.3:g.4102971C>G (rs804270) polymorphisms determined for 872 pts with newly diagnosed SCCOOP and 1,044 cancer-free non–Hispanic white controls frequency-matched by age and sex
Results
No overall differences between cases and controls in frequencies of alleles, genotypes, and haplotypes of NEIL1 g.46434077G>T and NEIL1 g.46438282C>G polymorphisms
NEIL2 g.4102971CC genotype associated with a significantly increased risk of SCCOOP
Increased risk highest among current alcohol drinkers, particularly in oropharyngeal cancer pts
NEIL2 g.4102971CC genotype significantly associated with SCCOOP of advanced stages
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