Seng TJ et al. – DLEC1 and MLH1 methylation has prognostic value in non-small cell lung carcinomas (NSCLC); concordant methylation may be a consequence of a long-range epigenetic effect in this region of chromosome 3p, as recently been described in other cancers Methods
Study of promoter methylation in the deleted in lung and oesophageal cancer 1 (DLEC1), MLH1 and other 3p genes in 239 NSCLC
Results
Methylation: DLEC1 in 38.7% of tumors; MLH1 in 35.7%; RARbeta in 51.7%; RASSF1A in 32.4%; BLU in 35.3%
Any 2 of the gene alterations were associated with each other except RARbeta
DLEC1 methylation was an independent marker of poor survival in the whole cohort and in squamous cell carcinoma
MLH1 methylation was prognostic, particularly in large cell cancer
Concordant methylation of DLEC1/MLH1 was the strongest independent indicator of poor prognosis in the whole cohort
Microsatellite instability and MLH1 expression loss were rare, suggesting that MLH1 promoter methylation does not lead to gene silencing in lung cancer
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