Top ovarian Articles in Oncology

Survival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis
Cancer Chemotherapy and Pharmacology, 10/15/2009

Lee SJ et al. – The ovarian metastatectomy significantly prolonged survival in CRC patients with ovarian metastases. The potential role of an ovarian metastatectomy in the ... prospectively studied. Methods Between 1996 and 2008, 83 CRC patients underwent oophorectomy 47 CRC patients with ovarian metastasis without resection were included in analysis Results Median age was younger (48 years) in oophorectomy group ... li> For ovary-specific survival (date of ovarian metastasis diagnosis to death), CRC patients with oophorectomy showed significantly more favorable survival rate than control group In univariate analyses, oophorectomy , unilaterality of ovarian metastasis , metastasis confined to ovaries [more...]

Preventing future cancers by testing women with ovarian cancer for brca mutations
Journal of Clinical Oncology, 10/22/2009

Kwon JS et al. – BRCA testing of women with ovarian cancer based on personal/family history of cancer or Ashkenazi Jewish ancestry is a cost-effective strategy to prevent future breast and ovarian cancers among FDRs. More inclusive ... Markov Monte Carlo simulation model to compare four criteria for BRCA testing in women with ovarian cancer: no testing (reference); only if personal history of breast cancer, family history of breast/ovarian cancer, or Ashkenazi Jewish ancestry; only if invasive serous cancer; any invasive ... outcome was incremental cost-effectiveness ratio (ICER) Model estimated number of future breast and ovarian cancer cases in FDRs Results BRCA testing based on personal/family history and ancestry could prevent future cases in FDRs with an ICER of $32,018 per year ... epithelial ovarian cancer could prevent more cancer cases, but at ICERs of $128,465 and $148,363 per LY gained, respectively [more...]

Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis
Fertility and Sterility, 10/14/2009

Matsuzaki S et al. – The findings suggest that the normal ovarian cortex surrounding endometriotic tissues is more severely affected by oxidative stress than ovarian cortex adjacent to other benign ovarian cysts. [more...]

Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer
BMC Cancer, 11/04/2009

Merritt MA et al. – The malignant potential of serous ovarian tumors, the most common ovarian tumor subtype, varies from benign to low malignant potential (LMP) tumors to frankly invasive ... authors compared their patterns of gene expression. The results highlight several genes that may play an important role across the spectrum of serous ovarian tumorigenesis. [more...]

Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis
International Journal of Clinical Oncology, 11/02/2009

Kobayashi H – Ovarian endometrioma could be viewed as a neoplastic process, particularly in perimenopausal women. Understanding the mechanisms of the development of endometriosis and elucidating its ... pathogenesis and pathophysiology are intrinsic to the prevention of endometriosis–associated ovarian cancer and the search for effective therapies. [more...]

Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas
BMC Cancer, 10/21/2009

Osterberg L et al. – In conclusion, we detected specific genetic alterations associated with resistance, of which some might be potential predictive markers of chemotherapy resistance in advanced ovarian serous carcinomas. Thus, further studies are ... these findings in an independent ovarian tumor series Methods To create the best opportunities for identifying genetic alterations of importance for resistance, homogenous tumor material concerning histology, stage and chemotherapy was selected Using high-resolution ... genomic hybridization (CGH), analyzed tumor genomes of 40 fresh-frozen stage III ovarian serous carcinomas, all uniformly treated with combination therapy paclitaxel/carboplatin Fisher's exact test used to identify significant differences Examined four genes in significant regions [more...]

Serum C-reactive protein in the differential diagnosis of ovarian masses
European Journal of Obstetrics & Gynecology and Reproductive Biology, 10/19/2009

Hefler–Frischmuth K et al. – Serum CRP is associated with the presence of malignant ovarian tumors independent of serum CA 125 and patients’ age and can therefore be used as additional diagnostic marker in the differential diagnosis of ovarian masses ... gynecology,gynecologic oncology,obstetrics/gynecology,radiology/diagnostics [more...]

Comparison of dysplasia profiles in stimulated ovaries and in those with a genetic risk for ovarian cancer
European Journal of Cancer, 10/20/2009

Dauplata J et al. – Findings of this study support a possible relationship between OED and the use of ovulation-stimulating drugs. The increased dysplasia score in stimulated and genetic risk ... dysplasia or intraepithelial ovarian neoplasia. The observation of dysplasia in the stimulated group may differentiate women at risk. Conversely, the fact that the dysplasia profile after stimulation differs from that in genetic risk ovaries suggests that ovarian stimulation may predispose to a ... Methods 124 patients who had undergone salpingo-oophorectomies or ovarian cystectomies between 1990 and 2005 reviewed Divided into 3 groups: (1) previous in vitro fertilisation (n=35); (2) prophylactic oophorectomies for genetic risk (n=27) and (3) fertile non-cancerous ... and dysplasia score calculated to quantify ovarian epithelial abnormalities Results Mean dysplasia score significantly higher in genetic risk and stimulated ovary groups than controls Cytological and architectural abnormalities more frequent in genetic risk group [more...]

Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions
American Journal of Obstetrics and Gynecology, 10/01/2009

Idahl A et al. – C trachomatis, M genitalium, N gonorrhoeae, HPV, and the polyomaviruses BKV and JCV are not detectable in ovarian tissues either from women with benign conditions and borderline tumors or from women with ovarian cancer ... hematology/oncology,general gynecology,gynecologic oncology,stds/infections,obstetrics/gynecology [more...]

Activity of the multikinase inhibitor dasatinib against ovarian cancer cells
British Journal of Cancer, 11/02/2009

Konecny GE et al. – These data provide a clear biological rationale to test dasatinib as a single agent or in combination with chemotherapy in patients with ovarian cancer. Methods Examined effects ... cycle arrest, and kinase activity using panel of 34 established human ovarian cancer cell lines Molecular markers for response prediction studied using gene expression profiling Multiple drug effect/combination index (CI) isobologram analysis was used to study interactions with ... dependent anti-proliferative effects of dasatinib were seen in all ovarian cancer cell lines tested, but varied significantly between individual cell lines with up to 3 log-fold difference in IC50 values Dasatinib significantly inhibited invasion, and induced cell apoptosis, but less cell ... additive and synergistic interactions observed for dasatinib plus carboplatin or paclitaxel 24 out of 34 (71%) representative ovarian cancer cell lines highly sensitive to dasatinib, compared with only 8 out of 39 (21%) representative breast cancer cell lines previously reported [more...]