Cardiology Medical News about Acute Coronary Syndrome Percutaneous coronary intervention prasugrel clopidogrel

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Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention
Vascular Health and Risk Management, 10/22/09

Norgard NB et al. – Clopidogrel, when added to aspirin, has demonstrated considerable success at reducing thrombotic complications of ACS and/or PCI compared to aspirin alone and is standard of care for the management of patients with ACS and in patients undergoing PCI. Prasugrel is a novel thienopyridine antiplatelet agent recently approved for the treatment of patients with ACS undergoing PCI. Prasugrel provides greater and more consistent platelet inhibition than clopidogrel due to earlier and more extensive formation of its active metabolite. The enhanced platelet inhibition with prasugrel led to a reduction in major adverse cardiovascular events in patients with moderate to high risk ACS scheduled for PCI in the phase 3 TRITON–TIMI 38 trial. This benefit was seen more in patients suffering a STEMI and those with diabetes. However, this reduction in events was met with a significant increase in the risk of bleeding which overcame prasugrel’s benefit in certain groups.

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Dual antiplatelet therapy in coronary artery disease: A case-based approach
Cleveland Clinic Journal of Medicine, 11/04/09 Relevance Score: 99%

Ticagrelor demonstrated greater efficacy over clopidogrel in the most urgent clinical setting: Patients with ST-Segment Elevation Myocardial Infarction and planned Percutaneous Coronary Intervention
AstraZeneca, 11/16/09 Relevance Score: 98%

Predictive Values of Post-Treatment Adenosine Diphosphate–Induced Aggregation and Vasodilator-Stimulated Phosphoprotein Index for Stent Thrombosis After Acute Coronary Syndrome in Clopidogrel-Treated Patients
The American Journal of Cardiology, 10/15/09 Relevance Score: 98%

Acute Coronary Syndromes: Diagnosis and Management, Part II
Mayo Clinic Proceedings, 11/03/09 Relevance Score: 97%

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Cardiology, 10/12/09 Relevance Score: 97%