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Statin Use is Associated with a Significant Reduction in Cholesterol Content of Erythrocyte Membranes. A Novel Pleiotropic Effect
Cardiovascular Drugs and Therapy, 10/21/09

Tziakas DN et al. – The present study showed, that use of statins is associated with a reduction in CEM, an emerging marker of clinical instability and plaque vulnerability in CAD patients. The pleiotropic effects of statins at the cell membrane level represent a promising novel direction for research in CAD.

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Dimitrios N. Tziakas, 10/21/09

We believe that as cholesterol content of erythrocyte membranes is identified as a novel marker for clinical instability in coronary artery disease new diagnostic and therapeutic approaches are emerging. Statins, whose prognostic benefit lies well beyond their lipid lowering effect seem a potent canditate that can modulate cholesterol metabolism at the cell membrane level

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