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Time-Dependent Effects of Low-Dose Aspirin on Plasma Renin Activity, Aldosterone, Cortisol, and Catecholamines
Hypertension, 10/12/09

Snoep JD et al. – Aspirin taken at bedtime compared with on awakening significantly diminished 24–hour plasma renin activity and excretion of cortisol, dopamine, and norepinephrine in 24–hour urine. Decreased activity of these pressor systems forms a biologically plausible explanation for the finding that aspirin at night may reduce blood pressure, whereas aspirin at morning does not.

Exclusive Author Commentary
Jaapjan D. Snoep, 10/13/09

Aspirin is generally not believed to influence blood pressure. However, several recent studies have suggested that aspirin, when taken at bedtime, reduces blood pressure, whereas aspirin intake in the morning does not affect blood pressure. Until now, a biologically plausible mechanism underlying this striking difference according to time of intake has not been provided. In a randomized crossover trial, we have found that aspirin at bedtime compared to on awakening reduces plasma renin activivity over 24h as well as cortisol and catecholamines in 24h urine. Time-dependent decreased activity of these pressor systems can explain the found differential effects of aspirin on blood pressure according to time of intake.