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Risk factors for development of coronary artery disease in women with systemic lupus erythematosus
Journal of Rheumatology, 10/20/2009
more CAD events than controls. Accounting for demographic variability, CAD risk factors, and lipid factors, SLE is an independent risk factor for the development of CAD.

Methods

  • SLE patients and non-SLE age-matched controls without a history of CAD recruited into prospective ... between 1997 and 1999
  • CAD events assessed at clinic visit for SLE patients and through telephone interview and chart review for controls
  • All events verified with medical records

Results
  • Followup information available on 237 controls and 241 SLE patients ... age and postmenopausal status as predictors of CAD in both groups
  • Sedentary lifestyle, hypertension, the presence of metabolic syndrome, and the number of Framingham risk factors predictive in control group only
  • 10-year risk of CAD score predictive in both groups but not as marked ... not predictive for CAD in SLE group
  • In controls, high triglyceride level ≥ 2.8 predictive
  • Time-to-event multivariate analysis for CAD in all subjects revealed SLE , older age, and triglycerides ≥ 2.8 to be highly predictive for CAD
[more...]

Coronary artery disease: Are men and women created equal?
Gender Medicine, 10/23/2009
pathways of CAD in women published in English within the past 10 years and epidemiologic studies published since 1970.

Results
  • The literature search revealed 30 peer–reviewed articles pertaining to this issue.
  • The incidence of CAD was markedly lower ... years of age than in older women.
  • After 60 years of age, the rate of CAD increased and reached the rate seen among men by the 8th decade of life.
  • The gender difference in atherosclerosis in the coronary tree was particularly large in patients <55 years of age and remained large ... body mass index (BMI) and metabolic status, but only the metabolic syndrome was associated with CAD.
  • Physical activity was independently associated with fewer risk factors, less CAD, and fewer adverse events in women; however, obesity was not associated with these outcomes.
[more...]

Intravenous Thrombolysis in Stroke Attributable to Cervical Artery Dissection
Stroke, 10/27/2009
with CAD do not recover as well as IVT–treated non–CAD patients. However, intracranial bleedings and recurrent ischemic strokes were equally frequent in both groups. They do not account for different outcomes and indicate that IVT should not be excluded in patients who may have CAD ... Hemodynamic compromise or frequent tandem occlusions might explain the less favorable outcome of patients with CAD. [more...]

Sexual activity and erectile dysfunction in elderly men with angiographically documented coronary artery disease
UroToday, 10/30/2009
Sexual Health Inventory for Males questionnaire. Lack of sexual activity was more prevalent among men with CAD relative to men without CAD. Among the sexually active men, ED was more prevalent among men with CAD relative to men without CAD. [more...]

Invasive breast cancers detected by screening mammography: A detailed comparison of computer-aided detection-assisted single reading and double reading
Journal of Medical Imaging and Radiation Oncology (JMIRO), 10/06/2009
recalled after arbitration and CAD–R were smaller. No difference in cancer size or sensitivity between reading methods was found with increasing breast density. CAD–R and BP sensitivity and cancer detection size were not significantly different. CAD–R specificity was significantly [more...]

Influence of coronary artery disease assessment and treatment in the incidence of cardiac events in renal transplant recipients
Clinical Transplantation, 11/18/2009
patients with or without CAD and positive for myocardial ischemia. Patients with altered scan and CAD had the poorer outcome. Guideline–oriented medical treatment is safe and yields results comparable to coronary intervention in renal transplant patients with CAD. The data do not support pre [more...]

Genetics and cardiovascular disease: Design and development of a DNA biobank
Experimental and Clinical Cardiology, 11/16/2009
encountered in the biobank is CAD. The significance of the familial occurrence of CAD has been the focus of research for at least 50 years, with a positive family history of CV disease emerging as an independent predictor of risk in the development of CAD. By applying the knowledge learned from [more...]

Enhanced neutrophil expression of annexin-1 in coronary artery disease
Metabolism-Clinical and Experimental, 10/26/2009
of the hypothalamic–pituitary–adrenal axis in CAD patients but do not give any evidence for glucocorticoid resistance, as assessed by the neutrophil expression of GR and ANXA1. The altered neutrophil phenotype in CAD may thus represent a long–term response to disease–related [more...]

Statin Use is Associated with a Significant Reduction in Cholesterol Content of Erythrocyte Membranes. A Novel Pleiotropic Effect
Cardiovascular Drugs and Therapy, 10/21/2009
in CEM, an emerging marker of clinical instability and plaque vulnerability in CAD patients. The pleiotropic effects of statins at the cell membrane level represent a promising novel direction for research in CAD. [more...]

Management of Coronary Artery Disease in Patients with Chronic Kidney Disease
Advances in Peritoneal Dialysis, 10/27/2009
Coats WC et al. – Risk factor modification remains the cornerstone of management of both CKD and CAD. Many of the traditional risk factors for CAD—hypertension, diabetes mellitus, smoking, and so on—are common to CKD. However, decreased renal function limits the clinician's ... adverse reactions from medications used to treat CAD. In addition, patients with CKD are more likely to experience complications following left heart catheterization, percutaneous coronary interventions, and coronary artery bypass grafting. [more...]

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