Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification
Journal of Rheumatology, 01/19/2010
are prone to premature atherosclerosis. We hypothesize that depletion of circulating endothelial progenitor cells (EPC) related to RA can contribute to the development of atherosclerosis. he results of this study demonstrated that RA patients with coronary atherosclerosis have significantly lower ... CD133+ EPC than those without. In addition to older age, lower levels of circulating CD133/KDR+ EPC also predicted occurrence of coronary atherosclerosis in RA patients. Methods- Studied coronary calcifications by multidetector computed tomography and their relationship with ... women)
- Presence of coronary atherosclerosis was defined as Agatston score ≥ 10
- 4 subpopulations of EPC were determined by flow cytometry on the basis of surface expression of CD34, CD133, and KDR antigen: CD34+, CD34/KDR+, CD133+, and CD133/KDR+ EPC
Resultsatherosclerosis Mean Agatston score was higher (61.8 ± 201.7 vs 0.14 ± 0.69) and coronary atherosclerosis was more prevalent (21.4% vs 0%) in patients with RA compared to controlsRA patients with coronary atherosclerosis were older (66.2 ± ... logistic regression revealed that older age (OR 1.25, 95% CI 1.10–1.41) and lower CD133/KDR+ EPC (OR 0.07, 95% CI 0.00–0.97) were independent predictors for coronary atherosclerosis in patients with RA
[more...]
|
Systemic atherosclerosis in patients with perforating artery territorial infarction
European Journal of Neurology, 01/25/2010
|
Choi HY et al. – Perforating artery territorial infarction with RAA or PAA when compared to PAI without atherosclerosis showed different involvement patterns of systemic atherosclerosis, suggesting ... different aetiological mechanisms.
[more...]
|
HDL and immunomodulation: an emerging role of HDL against atherosclerosis
Immunology & Cell Biology, 01/15/2010
|
Yu BL et al. – Lipid rafts in plasma membrane are the key structure responsible for the immunomodulation effects of HDL, the remarkable ability of HDL to regulate innate and adaptive immune responses extends our ... therapeutic approaches to atherosclerosis and other inflammatory conditions.
[more...]
|
Protease Imaging of Human Atheromata Captures Molecular Information of Atherosclerosis, Complementing Anatomic Imaging
Arteriosclerosis, Thrombosis, and Vascular Biology, 01/20/2010
|
Kim DE et al. – The results could justify and facilitate clinical trials to evaluate the use of protease–sensing molecular optical imaging in human atherosclerosis patients.
[more...]
|
ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21
Arteriosclerosis, Thrombosis, and Vascular Biology, 01/20/2010
|
Holdt LM et al. – The data provide robust evidence for an association of ANRIL but not CDKN2A, CDKN2B, C9orf53, and MTAP, with atherosclerosis and Chr9p21 genotype in a large cohort.
[more...]
|
Overexpression of Activated Nuclear Factor-k B in Aorta of Patients With Coronary Atherosclerosis
Clinical Cardiology, 01/04/2010
|
Zhang W et al. – This study demonstrates a highly activated NF–kB in aortas from patients with coronary atherosclerosis, which may reflect overall arterial overinflammatory status. The findings of ... the inflammation that is associated with and may cause atherosclerosis.
[more...]
|
Increased prevalence of carotid artery atherosclerosis in rheumatoid arthritis is artery-specific
Journal of Rheumatology, 02/04/2010
|
Kobayashi H et al. – Cardiovascular (CV) morbidity and mortality are increased in rheumatoid arthritis (RA). Prior investigations of the association of RA with measures of carotid atherosclerosis have yielded conflicting ... prevalence, between RA and non-RA participants. Compared to controls, RA was associated with a higher prevalence and higher severity of atherosclerosis in the bulb-ICA but not the CCA. Our data suggest that future studies in RA that utilize carotid artery measurements should include assessment of ... Non-RA controls selected from Multi-Ethnic Study of Atherosclerosis Both groups underwent B-mode ultrasonography of the right and left CCA and bulb-ICALinear regression used to model association of RA status with CCA and bulb-ICA-IMT, and logistic regression for the association of ... ICA-IMT and plaque in controls but not in RA patients In RA group, shared epitope associated with increased prevalence of plaque
[more...]
|
Regulations of the key mediators in inflammation and atherosclerosis by Aspirin in human macrophages
Lipids in Health and Disease, 02/08/2010
|
Lu L et al. – These results showed that ASA inhibited MMP–9 mRNA expression, and caused the decrease in the MMP–9 activities from the cell culture supernatants. In addition, it ... two molecules known to reduce the progression of atherosclerosis, at both mRNA and protein levels. It also stimulated the cholesterol efflux out of macrophages. These data suggest that acetyl salicylic acid may alleviate symptoms of atherosclerosis by two potential mechanisms: maintaining the plaque ... the cholesterol efflux through inducing expressions of ABCA1 and SR–BI.
[more...]
|
Ubiquitous atherosclerosis in coronary arteries without angiographically significant stenosis
Heart and Vessels, 01/27/2010
|
Ishio N et al. – There was no significant difference in normalized TPV, PPV, and the incidence of abnormal intimal thickness between coronary arteries with and without significant stenosis ... was similar. Atherosclerosis is ubiquitous even in coronary arteries without angiographically significant stenosis. The extent of atherosclerosis is similar between coronary arteries with and without significant stenosis.
[more...]
|
Burden of Cardiovascular Risk Factors, Subclinical Atherosclerosis, and Incident Cardiovascular Events Across Dimensions of Religiosity: The Multi-Ethnic Study of Atherosclerosis
Circulation, 01/26/2010
|
Feinstein M et al. – The results do not confirm those of previous studies associating greater religiosity with ... regard to CVD. There was no reduction in risk for CVD events associated with greater religiosity.
[more...]
|
