Your Article Summary
See Latest ArticlesConcurrent chemoradiotherapy with S-1 and cisplatin in advanced esophageal cancer
Diseases of the Esophagus, 08/20/08
Cho SH et al. - In a trial to evaluate the efficacy and safety of concurrent chemoradiotherapy with S-1 and cisplatin in advanced esophageal cancer, it was shown that the main hematological toxicity was neutropenia, but no neutropenic fever was observed. The major non-hematological toxicities were asthenia and vomiting, mostly of grades 1 and 2. Concurrent chemoradiotherapy with S-1 and cisplatin may be a promising nonsurgical treatment in advanced esophageal cancer
Methods- Pts with locally advanced or metastatic squamous cell carcinoma of the esophagus received S-1 and cisplatin at doses of 70 mg/m2/day for 14 days and 70 mg/m2 on day 1, respectively, every 3 weeks
- Concurrently, radiotherapy was started at a dose of 200 cGy/day, up to a total of 5400 cGy
- After concurrent chemoradiotherapy, additive chemotherapy was repeated up to 6 cycles
- 30 pts were enrolled; of the 27 in whom efficacy could be evaluated, an objective response rate was seen in 20, including 5 complete pathologic responses in primary lesions
- Improvement of dysphagia was seen in 21 pts
- In pts with stage II or III esophageal cancer, median progression-free survival and overall survival were 10.6 months, respectively
- In pts with stage IV esophageal cancer, median progression-free survival and overall survival were 5.4 months and 11.6 months, respectively
Related Articles
Association of C-Reactive Protein Levels and Long-Term Survival after Neoadjuvant Therapy and Esophagectomy for Esophageal Cancer
Journal of Gastrointestinal Surgery, 12/03/09
Relevance Score: 67%
Comparison of the short-term quality of life in patients with esophageal cancer after subtotal esophagectomy via video-assisted thoracoscopic or open surgery
Diseases of the Esophagus, 11/25/09
Relevance Score: 67%
Impact of lymph-node metastasis site in patients with thoracic esophageal cancer
Journal of Surgical Oncology, 11/19/09
Relevance Score: 67%
Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopy
Head & Neck, 11/06/09
Relevance Score: 67%
The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period
BMC Cancer, 11/02/09
Relevance Score: 67%
Today in Esophagus...keeping you current
Receive free subspecialty "5-minute updates" via email
Nausea Caused by a Jejunal Lipoma
Clinical Gastroenterology and Hepatology , 12/14/09
A laparoscopic vagus-preserving Merendino procedure for early esophageal adenocarcinoma
Surgical Endoscopy, 12/14/09
Pre-operative dental brushing can reduce the risk of postoperative pneumonia in esophageal cancer patients
Surgery, 12/14/09
Today in GI Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma
Cancer, 12/14/09
Nausea Caused by a Jejunal Lipoma
Clinical Gastroenterology and Hepatology , 12/14/09
Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population
World Journal of Gastroenterology, 12/14/09
Today in Pharmacology/kinetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Vascular Endothelial Growth Factor Plus Epidermal Growth Factor Receptor Dual Targeted Therapy in Metastatic Colorectal Cancer: Synergy or Antagonism
Journal of Oncology, 12/14/09
An Unusual Cause of Hematemesis
Clinical Gastroenterology and Hepatology , 12/14/09
Palliative treatment of unresectable metastatic colorectal cancer
Expert Opinion in Pharmacotherapy, 12/14/09