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See Latest ArticlesLow Rates of Hepatotoxicity in HIV-infected Children on Anti-retroviral Therapy with and Without Isoniazid Prophylaxis
Journal of Tropical Pediatrics, 08/27/09
Gray D et al. – There was no increased risk of hepatotoxicity with ART with or without isoniazid compared to the control group over a 2–year period. Grade 3 or 4 ALT elevations occurred in 19 children, with no cases of fulminant hepatic failure. Severe hepatic events are uncommon in children on ART or isoniazid. There is no increased risk of hepatotoxicity with ART and concurrent isoniazid preventive therapy.
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