Top hepatotoxicity Articles in Gastroenterology

Low Rates of Hepatotoxicity in HIV-infected Children on Anti-retroviral Therapy with and Without Isoniazid Prophylaxis
Journal of Tropical Pediatrics, 08/27/2009

Gray D et al. – There was no increased risk of hepatotoxicity with ART with or without isoniazid compared to the control group over a 2–year period. Grade 3 or 4 ALT ... are uncommon in children on ART or isoniazid. There is no increased risk of hepatotoxicity with ART and concurrent isoniazid preventive therapy. [more...]

The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid
Archives of Pharmacal Research, 08/10/2009

Lee MS et al. – The liver concentration of free 4–ene VPA and the urinary excretion of total 4–ene VPA were the only measures that correlated with the increase in ... authors conclude that hepatotoxicity of VPA correlates with liver concentration of 4–ene VPA and can be predicted by the urinary excretion of total 4–ene VPA. [more...]

The role of chronic hepatitis in isoniazid hepatotoxicity during treatment for latent tuberculosis infection
The International Journal of Tuberculosis and Lung Disease, 08/12/2009

Bliven EE et al. – Owing to the limited number of published papers, CVH was not established as a risk factor for INH hepatotoxicity during LTBI treatment. Controlled studies are [more...]

Atenolol Hepatotoxicity: Report of a Complicated Case
Annals of Pharmacotherapy, 09/25/2009

Dumortier J et al. – Despite the fact that Beta–blocker–induced hepatotoxicity is probably extremely rare, it must be suspected and the drug therefore discontinued. [more...]

Herbal and Dietary Supplement Hepatotoxicity
Seminars in Liver Disease, 10/16/2009

Navarro VJ et al. – Additional measures to prevent HDS–induced hepatotoxicity include greater consumer and provider awareness, increased spontaneous reporting, and reassessment of regulations regarding the manufacturing, distribution, and [more...]

Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning
Annals of Emergency Medicine, 08/05/2009

Yarema MC et al. – The risk of hepatotoxicity differed between the 20–hour and 72–hour protocols according to the time to initiation of acetylcysteine. It favored the 20–hour [more...]

Co-medications That Modulate Liver Injury and Repair Influence Clinical Outcome of Acetaminophen-Associated Liver Injury
Clinical Gastroenterology and Hepatology, 08/05/2009

Concomitant use of medications that have been shown in preclinical studies to modulate liver injury and/or repair influenced acetaminophen hepatotoxicity. Drugs that reduce injury or increase repair are protective, whereas those that exacerbate injury or reduce repair are detrimental [more...]

Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes
International Journal of Obesity, 11/02/2009

an improvement effect on insulin resistance. These results indicate that evo improves the undesirable effects of rosi, including adipogenesis, body weight gain and hepatotoxicity, while preserving its desirable blood–glucose–lowering effect. [more...]

Phase 1 multicenter study of vincristine sulfate liposomes injection and dexamethasone in adults with relapsed or refractory acute lymphoblastic leukemia
Cancer, 08/31/2009

at least 1 dose of VSLI The MTD of VSLE was 2.25 mg/m2 1 patient had grade 3 motor neuropathy, grade 4 seizure, and grade 4 hepatotoxicity at 2.4 mg/m2 The most common toxicities attributed to VSLI included peripheral neuropathy (55%) and constipation (53%) A CR was [more...]

Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi's sarcoma
Biologics: targets & therapy, 08/17/2009

localizes better to the tumor and has higher efficacy. Skin toxicity, mucositis, and leukopenia/neutropenia are the main side effects. Hepatotoxicity and mild cardiotoxicity are observed less frequently. Pegylated liposomal doxorubicin impacts favorably on quality of life. Although cost effective in [more...]