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Statin therapy, muscle function and falls risk in community-dwelling older adults
QJM: An International Journal of Medicine, 08/03/09

Scott D et al. – Statin use may exacerbate muscle performance declines and falls risk associated with aging without a concomitant decrease in muscle mass; this effect may be reversible with cessation.

Methods

Study of differences between statin users and non-users in muscle mass, muscle function and falls risk in a group of community-dwelling older adults
Prospective, population-based cohort study; mean follow-up of 2.6 yrs
Assessment of 774 older adults (48% female; mean age 62 yrs) at baseline and follow-up
Comparison of differences in percentage appendicular lean mass (%ALM), leg strength, leg muscle quality (LMQ; specific force) and falls risk for statin users vs non-users

Results

147 (19%) statin users at baseline; 179 (23%) at follow-up
On longitudinal analyses, statin use at baseline predicted increased falls risk scores over 2.6 yrs and trend towards increased %ALM
Statin users at both time points showed decreased leg strength and trended towards increased falls risk vs controls
Statin users at both baseline and follow-up showed decreased leg strength and LMQ vs pts who ceased statin use at follow-up

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