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n-3 fatty acids reduce arterial LDL-cholesterol delivery and arterial lipoprotein lipase levels and lipase distribution
Arteriosclerosis, Thrombosis, and Vascular Biology, 02/11/09
Chang CL et al. – Eucaloric high-fat diets enriched in saturated fat (SAT) or fish oil (n-3) decrease arterial total lipoprotein lipase (LpL) delivery and abrogate LDL-selective uptake (SU) in parallel with changing arterial wall LpL expression and distribution.
Methods- Study of how n-3 fatty acid rich diets influence arterial cholesterol delivery and arterial LpL levels
- Feeding C57BL/6 mice chow or eucaloric high-fat SAT or n-3 diets for 12 wks
- Injection with double radiolabeled or fluorescent-labeled human LDL to separately trace LDL-arterial cholesteryl ester (CE) and LDL-apoB uptake
- SAT and n-3 diets similarly increased plasma cholesterol levels
- n-3 diets lowered plasma triglyceride concentrations
- SAT increased arterial LDL-SU with significantly higher CE infiltration into aortic media
- n-3 markedly reduced total LDL uptake and CE deposition and abolished SU with LDL localized only in aortic intima
- Disparate patterns of CE deposition between diets consistent with distribution of arterial LpL—SAT diets induced higher LpL levels throughout the aorta
- n-3 diets decreased LpL levels and limited LpL expression to aortic intima
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