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Long-Term Safety of Recombinant Human Growth Hormone in Children
Journal of Clinical Endocrinology and Metabolism, 11/25/09
Bell J et al. – After more than 20 yr, leukemia, a major safety issue initially believed associated with GH, has not been confirmed, but other signals, including risk of second malignancies in patients previously treated with irradiation, have been detected or confirmed through the NCGS. These data further clarify the events associated with rhGH and, although confirming a favorable overall safety profile, they also highlight specific populations at potential risk.
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