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See Latest ArticlesUnraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach
Journal of Clinical Endocrinology and Metabolism, 11/25/09
Welsh P et al. – Greater adiposity conferred by FTO and MC4R SNPs led to higher CRP levels, with no evidence for any reverse pathway. Future studies should extend these findings to other circulating inflammatory parameters. This study illustrates the potential power of Mendelian randomization to dissect directions of causality between intercorrelated metabolic factors.
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