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Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis
Arthritis & Rheumatism, 11/09/09

Carbonare LD et al. – These results suggest that an alteration of osteoblastic differentiation may contribute to the pathogenesis of osteoporosis. The noninvasive approach used in the present study could be proposed as a useful tool for studying mesenchymal involvement in bone diseases.

• Osteogenic differentiation process in MSCs obtained from peripheral blood of 31 patients with osteoporosis and 20 normal donors
• Cells evaluated by colony-forming unit-fibroblastic assay and cultured in osteogenic medium to analyze transcription factors runt-related transcription factor 2 (RUNX-2) and Sp7 and bone-related genes COL1A1, SPARC, and SPP1 after 3, 8, and 15 days of differentiation
• To determine possible differences between 2 groups in terms of osteoclastic and osteoblastic activation, we quantified osteoprotegerin (OPG) and RANKL levels in supernatants of osteoblastic culture

• Circulating MSCs increased in osteoporosis patients compared with normal donors
• In contrast, gene expression analysis revealed down-regulation of RUNX2, Sp7, COL1A1, SPARC, and SPP1 in patients with osteoporosis, associated with lower OPG:RANKL ratio

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