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Diagnostic efficacy of midnight cortisol and midnight ACTH in the diagnosis and localisation of Cushings syndrome
Pituitary, 09/01/09
John M et al. – Classical tests for diagnosis of Cushing’s syndrome (CS) like urine free cortisol and dexamethasone suppression tests have limitations in various clinical settings. This study evaluated the usefulness of sleeping midnight serum cortisol (SMNC) as a diagnostic test for hypercortisolemia. A single midnight collection could identify all patients with CS and classify the ACTH status at the proposed cut offs.
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