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See Latest ArticlesBody mass index changes and chronic neuroleptic drug treatment for Tourette syndrome
Pediatric Neurology , 08/10/09
Degrauw RS et al.– For children and adolescents with Tourette syndrome treated >1 yr with neuroleptic agents, findings show that weight gain is not excessive for all cases.
Methods- Study of effects of neuroleptic agents on body mass index for age and sex (body mass index Z scores) in matched cohort of 16 neuroleptic-treated and 29 nonneuroleptic-treated children and adolescents with Tourette syndrome
- Assessment of growth parameters in 45 children, age 5-15 yrs, treated for 3-yr average (range, 1-6) with low doses of pimozide or risperidone
- Regression analysis for effects of neuroleptic treatment, age, duration, and treatment X duration interactions on changes in Z score
- Repeat measures analysis of variance for time course of changes
- Mean first-yr weight gain differed significantly (13.5 kg neuroleptic vs 3.2 kg nonneuroleptic)
- Long-term Z score changes did not differ significantly
- Repeated measures analysis of Z scores differed significantly by treatment, related to first-year changes only
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