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Loss of SNF5 expression correlates with poor patient survival in melanoma
Clinical Cancer Research, 10/12/09

Lin H et al. – Our data indicate that SNF5 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target.

Methods

Using tissue microarry and immunohistochemistry, SNF5 staining in 51 dysplastic nevi, 88 primary melanomas, and 48 metastatic melanomas evaluated
Studied chemosensitivity of melanoma cells with reduced SNF5 expression by siRNA using cell survival and apoptosis assays

Results

SNF5 expression reduced in metastatic melanoma compared with dysplastic nevi , in advanced primary melanoma (Clark's level V) compared with low risk Clark's level II melanoma , and in melanoma at sun-exposed sites compared with sun-protected sites
Strong correlation between negative SNF5 expression and worse 5-year survival in melanoma patients
Multivariate Cox regression analysis revealed negative SNF5 expression is independent prognostic factor to predict patient outcome in primary melanomas
Knockdown of SNF5 in melanoma cell lines resulted in significant chemoresistance