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Murphy M et al. – Tissue–specific deletion of Pbx1 in the corneal epithelium of mice results in corneal dystrophy and clouding that is apparent in newborns and progressively worsens with age. Thickening of the cornea epithelium is accompanied by stromal infiltration with atypical basal cells, severe disorganization of stromal collagen matrix, and loss of corneal barrier function. High epithelial cell turnover is associated with perturbed expression of developmental regulators and aberrant differentiation suggesting an important function for Pbx1 in determining corneal identity.


   

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